YAMASA CORPORATION Biochemicals Division

YAMASA CORPORATION Biochemicals Division

CONTACT YAMASA CORPORATION SITE

YAMASA CORPORATION Biochemicals Division

CONTACT YAMASA CORPORATION SITE

Custom synthesis at laboratory

Yamasa synthesize candidate compounds for new drugs required from discovery to early clinical stage at laboratory. Utilizing our experience of drug discovery research for anticancer drugs and antivirus drugs of nucleic acid related compounds, Yamasa synthesizes various nucleic acid related compounds whose sugar, nucleobase or phosphate is modified.

Not only in custom synthesis of small molecular nucleic acid related compounds, Yamasa can collaborate in development of monomers for oligonucleotides.

Flow of custom synthesis

Examples

Examples of sugar modification

Examples of base modification

Examples of phosphoras modification

References

  • 1) Nucleosides & Nucleotides, 15, 305 (1996)
  • 2) Nucleosides, Nucleotides and Nucleic Acids, 28, 1117 (2009)
  • 3) Nucleosides & Nucleotides, 14, 427 (1995)
  • 4) Bioorg. Med. Chem. Lett., 20, 6013 (2010)
  • 5) Tetrahedron, 53, 13315 (1997)
  • 6) J. Med. Chem., 43, 4516 (2000)
  • 7) Nucleosides, Nucleotides and Nucleic Acids, 23, 671 (2004)
  • 8) J. Org. Chem., 62, 3140 (1997)
  • 9) Bioorg. Med. Chem., 8, 1545 (2000)
  • 10) Tetrahedron Lett., 47, 591 (2006)
  • 11) Tetrahedron Lett., 44, 8605 (2003)
  • 12) Antiviral Chem. Chemother., 14, 161 (2004)
  • 13) Bioorg. Med. Chem. Lett., 22, 3072 (2014)
  • 14) Nucleosides & Nucleotides, 19, 955 (2000)

Inquiry by e-mail

Contact by e-mail

Inquiry by telephone

(Reception hours 9:00~17:30)